NEW YORK, Oct. 3, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

EpiCast Report: Acute Ischemic Stroke - Epidemiology Forecast to 2022 http://www.reportlinker.com/p01658562/EpiCast-Report-Acute-Ischemic-Stroke---Epidemiology-Forecast-to-2022.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology

EpiCast Report: Acute Ischemic Stroke - Epidemiology Forecast to 2022

Summary

Stroke occurs when the blood supply to the brain is blocked or interrupted, either by blood clots or ruptured blood vessels, depriving the brain of oxygen and nutrients, ultimately leading to the death of brain cells. Stroke is a major cause of death, morbidity, and long-term disability. To forecast the incident and prevalent cases of stroke in the 6MM, GlobalData epidemiologists selected studies that used the WHO definition of stroke: "rapidly developing clinical signs of focal disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin." This definition excludes cases of transient ischemic attacks (TIAs), which are neurological deficits lasting less than 24 hours. This report also provides the incident cases of AIS segmented by the TOAST (Trial of Org 10172 in Acute Stroke Treatment) criteria subtypes and the proportion of recurrent cases of AIS out of the total cases of AIS (total cases of AIS = incident cases of first-ever AIS + recurrent cases of AIS) in these major markets.

GlobalData epidemiologists forecast that the incident cases of AIS in the 6MM will increase by 20.10% over the next decade, from 1.25 million cases in 2012 to 1.50 million cases in 2022, with more than 50% of the cases being in the US alone. The number of prevalent cases of AIS in the 6MM will increase by 18.6% over the forecast period, from 9.48 million cases in 2012 to 11.24 million cases in 2022. The substantially higher number of prevalent cases of AIS compared with the number of incident cases indicates that a higher proportion of stroke victims survive after the event for longer time periods. However, these stroke survivors will live with serious disabilities, making stroke a major burden for the affected individual and the entire healthcare system in each country.

Scope

- The Acute Ischemic Stroke (AIS) EpiCast Report provides an overview of the risk factors, comorbidities and the global epidemiological trends for AIS in the six major markets (6MM: US, France, Germany, Italy, Spain, and UK). In addition, this report includes a 10-year epidemiological forecast of the incident cases of AIS (all new cases of a first-ever AIS in a defined population in a specified time period) and the prevalent cases of AIS (all survivors of a first-ever AIS in a defined population at a specified point in time) segmented by sex and age (ages 20–85+ years). This report also provides the incident cases of AIS segmented by the TOAST criteria subtypes and the proportion of recurrent cases of AIS out of the total cases of AIS.- The AIS epidemiology report is written and developed by Masters- and PhD-level epidemiologists.- The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 6MM.

Reasons to buy

- Develop business strategies by understanding the trends shaping and driving the global AIS market. - Quantify patient populations in the global AIS market to improve product design, pricing, and launch plans. - Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for AIS therapeutics in each of the markets covered. - Identify the percentage of each TOAST subtype among incident cases of AIS.Table of Contents

1 Table of Contents 41.1 List of Tables 61.2 List of Figures 72 Introduction 82.1 Catalyst 83 Epidemiology 103.1 Disease Background 103.2 Risk Factors and Comorbidities 123.2.1 Atrial fibrillation increases the risk of AIS by as much as 15times 133.2.2 Hypertension elevates the risk of AIS by more than three times 143.2.3 The risk of AIS is almost identical in obese men and women 153.2.4 The risk of AIS increases with the duration of diabetes 153.2.5 Smoking increases the risk of AIS, which varies with the number of cigarettes smoked 163.2.6 Age is a strong predictor of AIS in both men and women 173.2.7 A family history of stroke, particularly a paternal history, is a strong predictor of stroke 183.2.8 Race/ethnicity is a strong predictor of AIS, and the risk varies with the different subtypes of AIS 193.3 Global Trends 203.3.1 US 223.3.2 France 263.3.3 Germany 283.3.4 Italy 303.3.5 Spain 323.3.6 UK 343.4 Forecast Methodology 363.4.1 Sources Used 403.4.2 Forecast Assumptions and Methods -Incident Cases of AIS 473.4.3 Forecast Assumptions and Methods-Prevalent Cases of AIS 513.4.4 Forecast Assumptions and Methods -AIS Recurrence Rate (%) 543.4.5 Sources Not Used 553.5 Epidemiological Forecast for AIS (2012-2022) 573.5.1 Incidence 573.5.2 Prevalence 653.5.3 AIS Recurrence Rate (%) 713.6 Discussion 723.6.1 Conclusions on Epidemiology Trends 723.6.2 Limitations of the Analysis 733.6.3 Strengths of the Analysis 744 Appendix 764.1 Bibliography 764.2 About the Authors 824.2.1 Epidemiologists 824.2.2 Reviewers 834.2.3 Global Director of Epidemiology and Health Policy 844.2.4 Global Head of Healthcare 844.3 About GlobalData 854.4 About EpiCast 854.5 Disclaimer 85

List of Tables

Table 1: TOAST Classification of Subtypes of AIS 11Table 2: Risk Factors and Comorbidities for AIS 13Table 3: Trends in the Age-Adjusted Incidence Rates of Stroke in the US (per 100,000 Population) 23Table 4: Trend in the Crude Mortality Rate of Stroke in the US (per 100,000 Population), 1970-2008 24Table 5: Trends in the Age-Adjusted Prevalence (%) of Stroke in the US, Ages ?18 Years, 2006-2010 25Table 6: Trends in the Age-Adjusted Incidence Rates* of Stroke in France (per 100,000 Population) 26Table 7: Trends in the Age-Specific Prevalence of Stroke (per 100,000 Population) in France, 2000 27Table 8: Trends in the Crude Annual Incidence Rates of Stroke in Germany (per 100,000 Population) 28Table 9: Trends in the Age-Specific Prevalence of Stroke (per 100,000 Population) in Germany, 2000 29Table 10: Trends in the Total Crude Incidence Rates of Stroke in Italy (per 100,000 Population), All Ages 30Table 11: Trends in the Age-Specific Prevalence of Stroke (per 100,000 Population) in Italy, 2000 31Table 12: Trends in the Age-Adjusted Incidence Rates of Stroke in Spain (per 100,000 Population) 32Table 13: Trends in the Age-Specific Prevalence of Stroke (per 100,000 Population) in Spain, 2000 33Table 14: Trends in the Age-Adjusted Mortality Rate of Stroke in the UK (per 100,000 Population), 1981-2009 34Table 15: Trends in the Prevalence (%) of Stroke in the UK, 1994-2011 35Table 16:Sources of AIS Incidence Data 37Table 17:Sources of AIS Prevalence Data 38Table 18: Sources of AIS Recurrence (%) Data 39Table 19: Sources of AIS Subtypes (%) Data 39Table 20: 6MM, Incident Cases of AIS, Ages ?20 Years, Both Sexes, N, 2012-2022 57Table 21: 6MM, Incident Cases of AIS, by Age, Both Sexes, N, Row (%), 2012 59Table 22: 6MM, Incident Cases of AIS by Sex, Ages ?20 Years, N, Row (%), 2012 60Table 23: 6MM, Incident Cases of AIS by Subtypes, Ages ?20 Years, Both Sexes, N (Row %), 2012 63Table 24: 6MM, Prevalent Cases of AIS, Ages ?20 Years, Both Sexes, N, 2012-2022 65Table 25: 6MM, Prevalent Cases of AIS, by Age, Both Sexes, N, Row (%), 2012 67Table 26: 6MM, Prevalent Cases of AIS, Ages ?20 Years, by Sex, N, Row (%), 2012 68

List of Figures

Figure 1: Trends in the Age-Adjusted Incidence Rates of Stroke in the US (per 100,000 Population) 23Figure 2: Trend in the Crude Mortality Rate of Stroke in the US, Both Sexes (per 100,000 Population), 1970-2008 24Figure 3: Trends in the Age-Adjusted Prevalence (%) of Stroke in the US, Ages ?18 Years, 2006-2010 25Figure 4: Trends in the Age-Adjusted Incidence Rates* of Stroke in France (per 100,000 Population) 26Figure 5: Trends in the Age-Adjusted Mortality Rate of Stroke in the UK, Both Sexes (per 100,000 Population), 1981-2009 35Figure 6: Trends in the Prevalence (%) of Stroke in the UK, 1994-2011 36Figure 7: 6MM, Incident Cases of AIS, Ages ?20 Years, Both Sexes, N, 2012-2022 58Figure 8: 6MM, Incident Cases of AIS, by Age, Both Sexes, N, 2012 59Figure 9: 6MM, Incident Cases of AIS, by Sex, Ages ?20 Years, N, 2012 61Figure 10: 6MM, Age-Standardized Incidence of AIS (per 100,000 Population), Ages ?20 Years, by Sex, 2012 62Figure 11: 6MM, AIS Subtypes (%), Ages ?20 Years, Both Sexes, 2012 64Figure 12: 6MM, Incident Cases of AIS by Subtypes (N), Ages ?20 Years, Both Sexes, 2012 64Figure 13: 6MM, Prevalent Cases of AIS, Ages ?20 Years, Both Sexes, N, 2012-2022 66Figure 14: 6MM, Prevalent Cases of AIS, by Age, Both Sexes, N, 2012 67Figure 15: 6MM, Prevalent Cases of AIS, Ages ?20 Years, by Sex, N, Row (%), 2012 69Figure 16: 6MM, Age-Standardized Prevalence (%) of AIS, Ages ?20 Years, by Sex, 2012 70Figure 17: 6MM, Recurrence Rate (%) of AIS, Ages ?20 Years, Both Sexes, 2012 71

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